Clorgyline

ID: clorgyline

Aliases: clorgiline

Type: compound

Route/form: oral or route depends on studied product

Status: research

Evidence level: mechanistic

Best data tier: mechanistic/chemistry

Support scope: non-human/mechanistic, review/regulatory

Source types: database, mechanistic

Linked sources: 2

Broad outcomes: Brain / mood / sleep

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• irreversible MAO-A inhibitor

Optimization domains

• MAOI
• depression research
• monoamines

Research basis

• Selective irreversible MAO-A inhibition is a clear pharmacological probe.
• Useful comparator for MAO-A versus MAO-B risk.

Limits, risks, and missing evidence

• High-risk interaction profile; not a casual nootropic.
• Irreversibility means interaction risk can persist after discontinuation.

Risk flags

• MAOI
• drug interactions
• hypertensive crisis
• serotonin syndrome

Linked papers, labels, and reviews

1. PubChem: Clorgyline
   database / pubchem_clorgyline
   Chemical identity and literature links.
2. Parameters for irreversible inactivation of monoamine oxidase
   mechanistic / pubmed_maoi_irreversible_2020
   MAOI mechanism background.