Corylin

ID: corylin

Aliases: Psoralea corylifolia flavonoid

Type: compound

Route/form: oral/preclinical dietary flavonoid context

Status: research

Evidence level: preclinical

Best data tier: non-human experimental

Support scope: non-human/mechanistic, review/regulatory

Source types: preclinical, review

Linked sources: 3

Broad outcomes: Fat loss / metabolic health, Longevity / mitochondrial / redox

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• lifespan extension in high-fat-diet mouse model
• metabolic aging pathways
• oxidative stress and inflammation pathways

Optimization domains

• anti aging
• metabolic
• obesity
• lifespan
• natural product

Research basis

• The Nature Communications mouse paper reports lifespan and metabolic-health signals in a high-fat-diet model.
• It is a useful example of a natural-product aging lead with an actual in vivo paper rather than a pure forum claim.

Limits, risks, and missing evidence

• The evidence is mouse and context-specific; it does not establish human longevity benefit.
• Botanical-source, dose, formulation, hepatotoxicity, and broader Psoralea safety questions remain unresolved.

Risk flags

• preclinical only
• botanical source variability
• limited human data
• hepatotoxicity context
• translational gap

Linked papers, labels, and reviews

1. The flavonoid corylin exhibits lifespan extension properties in mouse
   preclinical / nature_corylin_lifespan_mouse_2022
   Mouse lifespan/metabolic-health source for corylin; high-fat-diet model, not human longevity evidence.
2. Corylin Inhibits Vascular Cell Inflammation, Proliferation and Migration and Reduces Atherosclerosis in ApoE-Deficient Mice
   preclinical / pubmed_corylin_atherosclerosis_mouse_2020
   Corylin vascular-inflammation/atherosclerosis mouse and cell source; useful related anti-inflammatory/metabolic-aging mechanism context.
3. A review of Psoralea corylifolia L.: a valuable plant with profound biological significance
   review / frontiers_psoralea_review_2025
   Botanical-source review covering Psoralea corylifolia phytochemistry, pharmacology, processing, and hepatotoxicity/safety context.