Dieckol

ID: dieckol

Aliases: Ecklonia cava dieckol

Type: compound

Route/form: route not curated

Status: research_or_supplement

Evidence level: preclinical

Best data tier: direct preclinical; adjacent human controlled/review

Support scope: human, non-human/mechanistic

Source types: human_rct, in_vitro, preclinical

Linked sources: 3

Broad outcomes: Cardiovascular / lipids / blood pressure

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• eNOS phosphorylation
• NADPH oxidase activity
• Treg/Th17 balance

Optimization domains

• cardiovascular health
• endothelial function
• blood pressure
• marine polyphenol

Research basis

• Spontaneously hypertensive rat work links dieckol/Ecklonia cava to endothelial-function markers including peNOS/eNOS, nitrate/nitrite, NADPH oxidase, and Treg/Th17 balance.
• Useful marine-polyphenol cardiovascular node.

Limits, risks, and missing evidence

• Animal endothelial-marker improvements do not establish clinical BP or cardiovascular-event benefit.
• Extract source, phlorotannin content, and iodine/heavy-metal quality issues need product-level review.

Risk flags

• preclinical only
• standardization uncertainty
• marine extract contaminants
• limited human data

Linked papers, labels, and reviews

1. Dieckol attenuates endothelial dysfunction via Th17/Treg balance in spontaneously hypertensive rats
   preclinical / pubmed_dieckol_endothelial_shr_2021
   Ecklonia cava/dieckol, peNOS/eNOS, nitrate/nitrite, NADPH oxidase, Treg/Th17 source.
2. Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in HUVECs
   in_vitro / sciencedirect_dieckol_huvec_2009
   Direct dieckol endothelial-cell oxidative-stress source; mechanistic only.
3. Effect of seaweed (Ecklonia cava extract) on blood glucose and insulin level on prediabetic patients
   human_rct / pubmed_ecklonia_prediabetes_rct_2022
   Human Ecklonia cava extract RCT; adjacent extract-level metabolic data, not isolated dieckol cardiovascular proof.