Delta Sleep-Inducing Peptide

ID: dsip

Aliases: DSIP, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

Type: compound

Route/form: older human sleep studies used IV injection; formulation varies by study and region

Status: research

Evidence level: early human

Best data tier: early human

Support scope: human, review/regulatory

Source types: human_trial, review

Linked sources: 3

Broad outcomes: Brain / mood / sleep

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• sleep architecture hypothesis
• stress/neuroendocrine modulation hypotheses
• uncertain endogenous peptide biology

Optimization domains

• sleep
• insomnia
• CNS
• stress

Research basis

• It is a good example where historical name recognition outpaces modern evidence quality.

Limits, risks, and missing evidence

• The evidence base is old, mixed, and not comparable to modern insomnia-drug trials.

Risk flags

• old mixed evidence
• limited human data
• CNS
• unapproved context

Linked papers, labels, and reviews

1. The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep
   human_trial / pubmed_dsip_human_sleep_1983
   Small older human chronic-insomnia study using intravenous synthetic DSIP.
2. Effects of DSIP in man: multifunctional psychophysiological properties besides induction of natural sleep
   human_trial / pubmed_dsip_insomnia_1987
   Older double-blind human DSIP psychophysiology/sleep studies; modern certainty is limited.
3. Delta-sleep-inducing peptide (DSIP): a review
   review / pubmed_dsip_review_1984
   Historical DSIP review across animal and human sleep/neuroendocrine literature.