Eucommia ulmoides Leaf Extract

ID: eucommia_ulmoides_leaf_extract

Aliases: duzhong leaf extract, Eucommia leaf extract

Type: botanical_extract

Route/form: oral supplement/extract unless otherwise specified

Status: supplement_or_research

Evidence level: preclinical

Best data tier: non-human experimental

Support scope: non-human/mechanistic, review/regulatory

Source types: preclinical, review

Linked sources: 2

Broad outcomes: Cardiovascular / lipids / blood pressure, Hormones / fertility / sexual health

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• Akt-eNOS pathway
• nitric oxide production
• oxidative stress
• HPG-axis markers

Optimization domains

• erectile quality
• cardiovascular health
• endothelial function
• botanical

Research basis

• A diabetic-rat erectile-dysfunction model reports improved erectile function, oxidative stress markers, NO production, Akt-eNOS activation, and HPG-axis markers.
• Useful as a vascular/endocrine botanical ED lead.

Limits, risks, and missing evidence

• Diabetic-rat ED findings do not establish human erectile benefit.
• HPG-axis marker changes should not be generalized to hormone optimization in healthy humans.

Risk flags

• preclinical only
• limited human data
• botanical identity
• endocrine claim caution

Linked papers, labels, and reviews

1. Eucommia ulmoides leaf extract improves erectile dysfunction in diabetic rats
   preclinical / pmc_eucommia_ed_2019
   STZ diabetic rat erectile function, Akt-eNOS, NO, oxidative stress, and HPG-axis source.
2. Traditional application and modern pharmacological research of Eucommia ulmoides Oliv.
   review / biomedcentral_eucommia_review_2021
   Broad Eucommia ulmoides pharmacology review that discusses erectile, metabolic, cardiovascular, and traditional-use claims.