EUK-134

ID: euk134

Aliases: manganosalen EUK-134, SOD/catalase mimetic

Type: compound

Route/form: topical in the human skin study; systemic manganosalen use is research context

Status: topical_cosmetic_or_research

Evidence level: early human

Best data tier: early human

Support scope: human, non-human/mechanistic, review/regulatory

Source types: human_trial, medicinal_chemistry, review

Linked sources: 4

Broad outcomes: Gut / immune / inflammation, Longevity / mitochondrial / redox, Skin / wound repair

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• superoxide dismutase mimetic
• catalase mimetic
• skin-surface lipid peroxide reduction

Optimization domains

• skin
• photoprotection
• oxidative stress
• anti aging
• redox
• inflammation

Research basis

• A human skin-surface study reports topical EUK-134 lowering baseline and UVA-induced lipid peroxides, which is a concrete photodamage/redox anchor.
• Manganosalen reviews show a broader in vivo redox-enzyme-mimetic literature for context.

Limits, risks, and missing evidence

• The human evidence is topical skin lipid-peroxide biology, not systemic longevity or whole-body antioxidant efficacy.
• Metal-complex redox biology can be dose- and context-dependent, and cosmetic-company evidence should be interpreted conservatively.

Risk flags

• topical context
• limited systemic human data
• redox biology
• dose response uncertainty
• cosmetic evidence context

Linked papers, labels, and reviews

1. Use of the synthetic superoxide dismutase/catalase mimetic EUK-134 to compensate for seasonal antioxidant deficiency by reducing pre-existing lipid peroxides at the human skin surface
   human_trial / pubmed_euk134_skin_lipid_peroxides_2004
   Human topical skin-surface study; supports lipid-peroxide/photodamage mechanism, not systemic anti-aging efficacy.
2. Pursuing the Elixir of Life: In Vivo Antioxidative Effects of Manganosalen Complexes
   review / mdpi_manganosalen_in_vivo_review_2020
   Review of in vivo manganosalen SOD/catalase-mimetic literature including EUK compounds and dose/context caveats.
3. Salen Mn complexes mitigate radiation injury in normal tissues
   review / pubmed_salen_mn_radiation_review_2011
   Review of salen-manganese complexes such as EUK-134, EUK-189, and EUK-207 in oxidative/radiation injury models.
4. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies
   medicinal_chemistry / pubmed_salen_manganese_sar_2002
   Chemistry/SAR source for salen-manganese SOD/catalase-mimetic properties including EUK-8 and EUK-134 context.