Forsythoside A

ID: forsythoside_a

Aliases: FTA

Type: compound

Route/form: topical or route depends on product/study

Status: research

Evidence level: preclinical

Best data tier: non-human experimental

Support scope: non-human/mechanistic

Source types: mechanistic, preclinical

Linked sources: 2

Broad outcomes: Hair / alopecia

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• TRPV3 inhibition
• DHT hair-follicle stress model

Optimization domains

• hair
• androgenetic alopecia
• TRPV3
• natural product

Research basis

• A 2025 preclinical paper links forsythoside A to TRPV3 inhibition and rescue of DHT-impaired hair-regrowth markers.
• Useful as a non-minoxidil hair-mechanism lead in the graph.

Limits, risks, and missing evidence

• No mature human androgenetic-alopecia outcome data were identified.
• Botanical source, formulation, skin penetration, and topical exposure are unresolved.

Risk flags

• preclinical only
• topical delivery unknown
• limited human data
• botanical identity

Linked papers, labels, and reviews

1. Forsythoside A alleviates androgenetic alopecia by selectively inhibiting TRPV3 channels in mice
   preclinical / pubmed_forsythosidea_trpv3_2025
   Mouse DHT-induced hair regrowth inhibition model and TRPV3 mechanism.
2. Pharmacological inhibition of TRPV3 by natural forsythoside B attenuates pruritus and cytotoxicity of keratinocytes
   mechanistic / sciencedirect_forsythosideb_trpv3_2019
   Related TRPV3-inhibitor source for the same phenylethanoid-glycoside/TRPV3 hair-skin mechanism family; not direct forsythoside A hair-regrowth evidence.