GHRP-2 / Pralmorelin

ID: ghrp2

Aliases: GHRP-2 ACETATE, GHRP-2, pralmorelin, KP-102

Type: compound

Route/form: injection in human physiology/diagnostic contexts; formulation varies by study

Status: regional_diagnostic_or_research

Evidence level: early human

Best data tier: human physiology

Support scope: human, review/regulatory

Source types: human_physiology, review

Linked sources: 3

Broad outcomes: Fat loss / metabolic health, Hormones / fertility / sexual health, Muscle growth / performance / recovery, PEDs / AAS / thermogenics

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• ghrelin receptor / GHSR agonism
• growth hormone release
• appetite stimulation

Optimization domains

• growth hormone
• endocrine
• appetite
• muscle

Research basis

• GHRP-2/pralmorelin has human physiology data showing GH release and ghrelin-like appetite effects in healthy men.
• It is useful in the graph as a GHSR/ghrelin-receptor comparator to ipamorelin, hexarelin, and GHRP-6.
• The strongest evidence is endocrine and appetite physiology, not body-composition outcomes.

Limits, risks, and missing evidence

• A GH pulse does not equal proven hypertrophy, repair, fat loss, or anti-aging benefit.
• Appetite increase can work against fat-loss goals, and GH-axis glucose/edema issues remain relevant.
• Older GHRP-class agents can have less selective prolactin/cortisol and desensitization profiles than the marketing implies.

Risk flags

• investigational
• endocrine axis
• ghrelin receptor
• appetite signal
• limited outcome data

Linked papers, labels, and reviews

1. Growth hormone releasing peptide-2, like ghrelin, increases food intake in healthy men
   human_physiology / pubmed_ghrp2_food_intake_men_2005
   Human GH/ghrelin physiology and appetite context for GHRP-2/pralmorelin.
2. Robust growth hormone responses to GH-releasing peptide 2 in adolescents
   human_physiology / pubmed_ghrp2_adolescent_gh_response_2024
   Human diagnostic GH response context.
3. Growth hormone-releasing peptides
   review / pubmed_ghrp_review_1997
   Class review for GHRP-2, GHRP-6, hexarelin, and related secretagogues.