Glutathione

ID: glutathione

Aliases: GSH, reduced glutathione, IV glutathione

Type: compound

Route/form: oral/topical/IV depending context; IV wellness use is compounded/off-label

Status: supplement_or_compounded

Evidence level: human RCT

Best data tier: human controlled/review; exact-use indirect

Support scope: human

Source types: systematic_review

Linked sources: 2

Broad outcomes: Gut / immune / inflammation, Longevity / mitochondrial / redox, Skin / wound repair

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• redox buffering
• glutathione peroxidase/reductase system
• melanin/skin-pigment pathways in dermatology claims

Optimization domains

• redox
• skin
• liver
• detox claims
• mitochondrial

Research basis

• Human dermatology evidence exists for systemic glutathione skin-color endpoints.
• Mechanistically central to cellular redox biology and antioxidant recycling.

Limits, risks, and missing evidence

• Skin-lightening data do not validate broad detox, longevity, or performance claims.

Risk flags

• route specific evidence
• skin lightening context
• iv compounding risk
• claims often overextended

Linked papers, labels, and reviews

1. The clinical effect of glutathione on skin color and other related skin conditions: a systematic review
   systematic_review / pubmed_glutathione_skin_systematic_review_2019
   Human skin-lightening/skin endpoints; not a global detox or anti-aging proof.
2. Systemic glutathione as a skin-whitening agent in adult
   systematic_review / pubmed_glutathione_skin_systemic_2020
   Systemic glutathione dermatology evidence synthesis with safety caveats.