Gynostemma pentaphyllum Extract

ID: gynostemma_pentaphyllum_extract

Aliases: jiaogulan extract, gypenoside L extract

Type: botanical_extract

Route/form: oral supplement/extract unless otherwise specified

Status: supplement_or_research

Evidence level: human RCT

Best data tier: human controlled/review

Support scope: human

Source types: human_rct

Linked sources: 2

Broad outcomes: Cardiovascular / lipids / blood pressure, Muscle growth / performance / recovery

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• eNOS
• muscle oxygen flux
• AMPK/ACC signaling
• VO2max

Optimization domains

• exercise performance
• endothelial function
• fatigue
• botanical

Research basis

• Human trials report improved VO2max, oxygen-pulse/perceived-fatigue endpoints, and time-trial performance signals with Gynostemma extract preparations.
• A useful exercise-performance botanical because it has human trial data rather than only animal endurance claims.

Limits, risks, and missing evidence

• Different preparations and gypenoside content may not be interchangeable.
• Small samples and performance endpoints need replication before ranking high.

Risk flags

• standardization uncertainty
• extract standardization
• limited replication
• exercise context specific

Linked papers, labels, and reviews

1. Gypenoside L-containing Gynostemma pentaphyllum extract improves fatigue and physical performance
   human_rct / pubmed_gynostemma_gypenoside_l_2023
   Double-blind randomized trial in 100 healthy adults.
2. Gynostemma pentaphyllum increases exercise performance and alters mitochondrial respiration and AMPK
   human_rct / mdpi_gynostemma_exercise_2023
   Randomized crossover trial in healthy untrained males.