M40401

ID: m40401

Aliases: SOD mimetic M40401

Type: compound

Route/form: route not curated

Status: research

Evidence level: preclinical

Best data tier: non-human experimental

Support scope: non-human/mechanistic

Source types: preclinical

Linked sources: 3

Broad outcomes: Gut / immune / inflammation, Longevity / mitochondrial / redox

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• superoxide scavenging
• peroxynitrite-related injury
• adhesion molecule expression

Optimization domains

• anti aging
• oxidative stress
• inflammation
• ischemia reperfusion

Research basis

• Preclinical injury models report protection consistent with reduced superoxide/peroxynitrite-linked inflammatory damage.
• Useful as an antioxidant-enzyme-mimetic comparator rather than a generic antioxidant supplement.

Limits, risks, and missing evidence

• The cited evidence is disease-model pharmacology, not human anti-aging evidence.
• SOD mimetic biology is context-specific and can shift redox signaling.

Risk flags

• preclinical only
• redox biology
• limited human data
• investigational

Linked papers, labels, and reviews

1. M40401 SOD mimetic reduces cerulein-induced acute pancreatitis
   preclinical / pubmed_m40401_pancreatitis_2004
   SOD mimetic source for adhesion molecule, nitrotyrosine, PARP, lipid peroxidation, and neutrophil-injury pathway claims.
2. Protective effects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion
   preclinical / pubmed_m40401_sao_2001
   Direct M40401 ischemia-reperfusion source for adhesion molecules, peroxynitrite-linked injury, and neutrophil-mediated tissue damage.
3. The protective effect of M40401, a superoxide dismutase mimetic, on post-ischemic brain damage in Mongolian gerbils
   preclinical / pmc_m40401_brain_ischemia_2003
   Additional M40401 ischemia-reperfusion model; supports redox/neuroprotection context, not human anti-aging evidence.