Oleracein E

ID: oleracein_e

Aliases: Portulaca oleracea alkaloid E

Type: compound

Route/form: oral or route depends on studied product

Status: research

Evidence level: preclinical

Best data tier: non-human experimental

Support scope: non-human/mechanistic

Source types: mechanistic, preclinical

Linked sources: 3

Broad outcomes: Brain / mood / sleep, mTORC / autophagy / nutrient signaling

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• ERK1/2-mTOR axis
• senescent hippocampal neural stem cells
• vascular dementia model

Optimization domains

• cognitive support
• neurogenesis
• vascular dementia
• natural product
• mTOR signaling

Research basis

• A 2025 preclinical paper reports rejuvenation of senescent hippocampal neural stem cells and improved cognition in vascular-dementia models through ERK1/2-mTOR inhibition.
• Adds a specific natural-product neurogenesis/senescence node.

Limits, risks, and missing evidence

• Disease-model cognitive rescue should not be generalized to healthy users.
• mTOR/ERK signaling is broad and could have context-dependent tradeoffs.

Risk flags

• preclinical only
• limited human data
• broad signaling pathway
• CNS unknowns

Linked papers, labels, and reviews

1. Oleracein E rejuvenates senescent hippocampal NSCs by inhibiting the ERK1/2-mTOR axis
   preclinical / ovid_oleracein_e_2025
   Vascular dementia/cognitive dysfunction source; limited public abstract access.
2. Protective effect of a phenolic extract containing indoline amides from Portulaca oleracea against cognitive impairment
   preclinical / pubmed_portulaca_indoline_cognition_2017
   Related Portulaca/indoline-amide mouse cognition source; adjacent to oleracein chemistry and cognition, not a pure oleracein E human study.
3. Bioactivity and Compound Identification in Extracts from Three Australian Populations of Portulaca oleracea
   mechanistic / pubmed_portulaca_oleracein_characterization_2025
   Oleracein structural/antioxidant characterization source for purslane chemistry; not direct vascular-dementia efficacy.