Oroxylin A

ID: oroxylin_a

Aliases: 5,7-dihydroxy-6-methoxyflavone

Type: compound

Route/form: oral supplement/food component unless otherwise specified

Status: research

Evidence level: preclinical

Best data tier: non-human experimental

Support scope: non-human/mechanistic

Source types: preclinical

Linked sources: 2

Broad outcomes: Brain / mood / sleep

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• adult hippocampal neurogenesis
• BDNF signaling
• memory impairment models

Optimization domains

• cognitive support
• neurogenesis
• memory
• natural product

Research basis

• Preclinical literature links oroxylin A to adult hippocampal neurogenesis and memory improvements in impaired models.
• Good example of a natural-product nootropic claim with identifiable mechanisms.

Limits, risks, and missing evidence

• No robust healthy-human cognition data were identified.
• Neurogenesis claims are especially prone to overtranslation from rodents.

Risk flags

• preclinical only
• limited human data
• CNS unknowns
• reddit sparse human data caution

Linked papers, labels, and reviews

1. Oroxylin A enhances memory consolidation through BDNF in mice
   preclinical / pubmed_oroxylina_bdnf_memory_2014
   Mouse memory consolidation and hippocampal BDNF source.
2. Oroxylin A stimulates adult neurogenesis in the hippocampal dentate gyrus region of mice
   preclinical / khu_oroxylina_neurogenesis
   Institutional record for mouse hippocampal neurogenesis paper.