PEG-MGF / Pegylated Mechano Growth Factor

ID: peg_mgf

Aliases: PEG MGF, PEG-MGF, mechano growth factor, IGF-1Ec analog

Type: compound

Route/form: human performance evidence is not supportive; no approved human performance route

Status: research

Evidence level: human RCT

Best data tier: human controlled/review

Support scope: human, non-human/mechanistic

Source types: human_rct_negative, mechanistic

Linked sources: 2

Broad outcomes: Muscle growth / performance / recovery, PEDs / AAS / thermogenics, Safety / regulatory

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• IGF-1 splice-variant / MGF hypothesis
• muscle repair and satellite-cell signaling claims

Optimization domains

• muscle growth
• recovery
• igf axis
• doping

Research basis

• MGF biology has a mechanistic relationship to muscle loading and IGF-1 splice variants.

Limits, risks, and missing evidence

• Human evidence does not support the strong bodybuilding claims typically attached to PEG-MGF.

Risk flags

• human negative signal
• IGF axis
• doping risk
• unapproved context
• identity uncertain

Linked papers, labels, and reviews

1. Recombinant human mechano growth factor does not improve muscle strength or performance in healthy men
   human_rct_negative / pubmed_pegmgf_athlete_trial_2014
   Human trial warning against assuming MGF/PEG-MGF has meaningful performance effects.
2. Biological activity of the E domain of the IGF-1Ec as addressed by synthetic peptides
   mechanistic / pubmed_mgf_review_2010
   Mechanistic IGF-1Ec/MGF peptide background; not equivalent to direct clinical hypertrophy evidence.