Piceatannol

ID: piceatannol

Aliases: 3,3',4,5'-tetrahydroxystilbene

Type: compound

Route/form: oral supplement/food component unless otherwise specified

Status: supplement_or_research

Evidence level: human RCT

Best data tier: human controlled/review

Support scope: human

Source types: human_rct, human_rct_negative

Linked sources: 2

Broad outcomes: Cardiovascular / lipids / blood pressure, Fat loss / metabolic health

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• insulin sensitivity
• vascular/metabolic signaling
• polyphenol redox signaling

Optimization domains

• metabolic health
• insulin sensitivity
• blood pressure
• polyphenol

Research basis

• An overweight-men randomized trial reported improved metabolic-health markers, including insulin sensitivity and hemodynamic measures.
• Fits the optimization interest in supplement-like metabolic adjuncts with at least some human data.

Limits, risks, and missing evidence

• Signals are population- and endpoint-specific and should not be generalized to fat loss.
• A later human study found no meaningful effect on fat metabolism in healthy adults.

Risk flags

• supplement
• mixed human data
• subgroup signal
• limited replication

Linked papers, labels, and reviews

1. The effect of piceatannol from passion fruit seeds on metabolic health in humans
   human_rct / mdpi_piceatannol_metabolic_health_2017
   Overweight-men subgroup showed reduced insulin, HOMA-IR, BP, and HR; effects were not broad across all groups.
2. Seven days of piceatannol supplementation exerted no effect on fat metabolism
   human_rct_negative / pubmed_piceatannol_no_fat_metabolism_2025
   Short crossover trial found no effect on fat metabolism at rest or during/after exercise.