Spilanthes acmella Extract

ID: spilanthes_acmella_extract

Aliases: Acmella oleracea, toothache plant extract, jambu extract

Type: botanical_extract

Route/form: oral supplement/extract unless otherwise specified

Status: supplement_or_traditional_use

Evidence level: preclinical

Best data tier: non-human experimental

Support scope: non-human/mechanistic, review/regulatory

Source types: preclinical, review

Linked sources: 2

Broad outcomes: Hormones / fertility / sexual health

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• N-alkylamides
• sexual behavior model

Optimization domains

• hormone optimization
• libido
• botanical
• sexual health

Research basis

• In vitro and in vivo work supports aphrodisiac potential and implicates N-alkylamides as candidate active constituents.
• Adds a source-backed libido botanical rather than a purely anecdotal entry.

Limits, risks, and missing evidence

• Preclinical sexual-behavior models are weak surrogates for human libido or endocrine outcomes.
• Extract standardization and contaminant testing matter.

Risk flags

• preclinical only
• botanical identity
• limited human data
• extract standardization

Linked papers, labels, and reviews

1. Spilanthes acmella ethanolic flower extract: alkylamide profiling and sexual behavior in male rats
   preclinical / pubmed_spilanthes_acmella_2011
   In vitro and rat sexual-behavior source for N-alkylamide aphrodisiac claims.
2. N-alkylamides of Spilanthes (syn: Acmella): Structure, purification, characterization, biological activities and applications
   review / sciencedirect_spilanthes_alkylamide_review_2021
   Review of Spilanthes/Acmella N-alkylamide chemistry and biological activity claims, including aphrodisiac context.