Yohimbine

ID: yohimbine

Aliases: yohimbine HCl

Type: compound

Route/form: oral

Status: prescription_or_supplement_context_dependent

Evidence level: human RCT

Best data tier: human controlled/review

Support scope: human, review/regulatory

Source types: government_fact_sheet, human_physiology, human_rct, human_trial

Linked sources: 4

Broad outcomes: Fat loss / metabolic health, Hormones / fertility / sexual health, PEDs / AAS / thermogenics, Safety / regulatory

Reading note: These are curation notes anchored to linked sources, not a clinical recommendation or protocol.

Targets / mechanism

• alpha-2 adrenergic antagonist

Optimization domains

• fat loss
• stimulant
• sexual function

Research basis

• Alpha-2 antagonism plausibly increases catecholamine tone and lipolysis under specific conditions.
• Direct human physiology data show oral yohimbine can mobilize lipids, and small human trials report body-weight or fat-mass signals.
• This makes yohimbine more than a purely mechanistic fat-loss claim while still keeping the evidence narrow.

Limits, risks, and missing evidence

• The human efficacy evidence is small and context-specific, not a broad or high-confidence fat-loss case.
• Anxiety, blood pressure, panic, arrhythmia, and stimulant/MAOI interactions can dominate utility.
• Fast-state lipolysis logic should not be treated as guaranteed fat loss in normal mixed-diet conditions.

Risk flags

• cardiovascular
• anxiety
• drug interactions

Linked papers, labels, and reviews

1. Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers
   human_physiology / pubmed_yohimbine_lipid_mobilization_1988
   Direct human lipolysis physiology anchor for alpha-2 antagonism; not an obesity-outcome trial.
2. Does yohimbine act as a slimming drugbeta
   human_trial / pubmed_yohimbine_obesity_trial_1991
   Small human obesity trial under low-energy diet conditions.
3. Yohimbine: the effects on body composition and exercise performance in soccer players
   human_rct / pubmed_yohimbine_soccer_players_2006
   Randomized controlled trial in elite soccer players; fat-mass endpoint with limited generalizability.
4. NIH ODS: Dietary supplements for weight loss - yohimbe/yohimbine section
   government_fact_sheet / nih_ods_yohimbe_weight_loss
   Summarizes weak weight-loss evidence and cardiovascular/anxiety toxicity reports.