• Clomipramine (approved / labelled) - OCD, anxiety, depression
• Clonidine (approved / labelled) - ADHD, anxiety, sleep
• Dexmedetomidine (approved / labelled) - anxiolysis, sedation
• Dextroamphetamine (approved / labelled) - ADHD, cognition, narcolepsy, wakefulness
• Diphenhydramine (approved / labelled) - dementia, insomnia, sedation, sleep
• Fenfluramine (approved / labelled) - epilepsy, serotonin, sigma1
• Flecainide (approved / labelled) - glial connexins, wakefulness combo
• Hydroxyzine (approved / labelled) - anxiety, insomnia, sedation, sleep
• Lisdexamfetamine (approved / labelled) - ADHD, cognition, wakefulness
• Methylphenidate (approved / labelled) - ADHD, cognition, narcolepsy, wakefulness
• Nebivolol (approved / labelled) - anxiety physical symptoms
• Oxytocin (approved / labelled) - CNS, social cognition
• Racemic Amphetamine Sulfate (approved / labelled) - ADHD, cognition, narcolepsy, wakefulness
• Selegiline (approved / labelled) - MAOI, Parkinsons, depression
• Sertraline (approved / labelled) - OCD, anxiety, depression, panic
• Trazodone (approved / labelled) - anxiety, depression, insomnia, serotonin, sleep
• Vitamin B12 / Cobalamin (approved / labelled) - neurology
• Carnosine / Beta-Alanine (human RCT) - cognition
• Cerebrolysin (human RCT) - cognition, neurorehabilitation, stroke, traumatic brain injury
• Creatine (human RCT) - cognition, sleep deprivation
• CVN424 (human RCT) - cognitive support, motor function, parkinsons disease
• Doxycycline (human RCT) - mental acuity
• Esmirtazapine (human RCT) - histamine, insomnia, sleep
• Ibutamoren (human RCT) - sleep
• NADH (human RCT) - cognitive support
• THN102 (human RCT) - cognition, narcolepsy, sleep deprivation, wakefulness
• Vornorexant (human RCT) - CNS, insomnia, orexin, sedation, sleep
• ARA-290 / Cibinetide (early human) - neuropathy, neuroprotection, small fiber neuropathy
• CJC-1295 No DAC / Modified GRF(1-29) (early human) - sleep
• Cutamesine (early human) - cognition, neuroprotection, stroke recovery
• Delta Sleep-Inducing Peptide (early human) - CNS, insomnia, sleep
• Elunetirom (early human) - CNS, bipolar depression, depression, myelin
• NAD+ / Intravenous NAD (early human) - neuro
• Pinealon (early human) - neuroprotection
• Selank (early human) - CNS, anxiety, cognition, nootropic
• Semax (early human) - CNS, cognition, neuroprotection, nootropic, stroke
• (-)-BPAP (preclinical) - CNS, dopamine, motivation
• 522-054 (preclinical) - attention, cognition, schizophrenia
• Arginine (preclinical) - alzheimers disease models, cognitive support
• BPC-157 (preclinical) - neuroprotection
• Dehydroevodiamine HCl (preclinical) - cognitive support, memory
• Dihexa (preclinical) - Alzheimers, CNS, cognition, neuroprotection, synaptogenesis
• Epitalon / Epithalon (preclinical) - sleep
• Imidazenil (preclinical) - anxiety, sedation, seizure
• Irdabisant (preclinical) - cognition, histamine, wakefulness
• Oleracein E (preclinical) - cognitive support, neurogenesis, vascular dementia
• Oroxylin A (preclinical) - cognitive support, memory, neurogenesis
• P21 / P021 Peptide (preclinical) - alzheimers model, neuroprotection, nootropic
• PE-22-28 (preclinical) - depression model, mood, nootropic
• Schisandrin B (preclinical) - GABA, cognitive support, seizure models
• Trigonelline (preclinical) - cognitive support
• Adamax (mechanistic) - neuroprotection, nootropic
• Clorgyline (mechanistic) - MAOI, depression research, monoamines
• Mexidol (mechanistic) - anxiety, neuroprotection
• Declozindol (unresolved) - ADHD, orexin, wakefulness